Agent Leon Kennedy is on a mission to rescue Dr. Antonio Taylor, but a mysterious woman gets in the way. Meanwhile, Agent Chris Redfield investigates a zombie outbreak in San Francisco, where the cause of the infection cannot be determined. The only thing that unites the victims is that they all recently visited Alcatraz Island. Following this hint Chris and his team go to the island, where a new horror awaits them.

全世界でシリーズ累計出荷本数が1億3,000万本を超えるサバイバルホラーゲームの金字塔「バイオハザード」。
その最新CG長編映画「バイオハザード：デスアイランド」の公式コミカライズ。
クリスとレオン達はお互いに異なる事件を辿り、監獄島・アルカトラズへの引き寄せられていく…。